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huH-1 |
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| Product Name |
huH-1 |
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| Price | Get Quote | |||
| Product Code | huH-1; HUH-1; huH 1; HuH1; HUh1; HUH1; huH1 |
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| Cat.No |
ABC-TC0434 |
Species |
Human |
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| Size/Quantity |
1 vial |
Biosafety Level |
1 |
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| Shipping Info |
Dry Ice |
Storage |
Liquid Nitrogen |
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| Description |
Why choose huH-1 from AcceGen? AcceGen provides huH-1 cell line with high standards of sterility, being negative for bacterial, fungal, and mycoplasma, to ensure the safety and integrity of the product. The huH-1 cell line is supported by excellent production and cryopreservation methods, ensuring high viability and maximum growth performance. |
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| Disease | Hepatocellular Cancer |
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| Source Organ | Liver |
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| Recommended Medium And Supplement | DMEM + 10% FBS |
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| Citation Guide |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID). |
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| Application | FOR RESEARCH USE ONLY For many years, huH-1 has been widely employed as a valuable research tool to investigate HBV and its association with carcinogenesis. HCC is a high-risk malignant tumor, and its 5-year survival rate is below 50%. The precise understanding of the pathogenesis of HCC remains incomplete. huH-1 can be used to study the pathogenesis of HCC and screen for effective diagnostic markers and therapeutic targets. |
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| Growth Conditions | 37 ℃, 5% CO2 |
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| Cell Type | Epithelial-like |
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| Product Type |
Human Liver Cancer Cell Lines |
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| Product Image |
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The huH-1 is a human hepatocellular carcinoma (HCC) cell line derived from the liver tissue of a patient with adult hepatocellular carcinoma. Hepatitis B virus (HBV) is detected in the huH-1 cell line with a high transcriptional activity, and hepatitis B surface antigen (HBsAg) can be produced by huH-1. The huH-1 presents the typical characteristics of epithelial morphology and expresses several biomarkers of epithelial-mesenchymal transition, such as E-cadherin, ZO-1, N-cadherin, Vimentin, Snail, and Slug. Otherwise, the chromosomal translocation is also identified in huH-1; an integration event occurs between chromosome 9 and 20 with a fusion of 1100bp HBV DNA.
Frequently Asked Questions
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What are huH-1 cells?
huH-1 cells were originally isolated from liver of hepatocellular carcinoma, HBs-antigen carrier patient. Modal chromosome number is 69.
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What culture medium is recommended for huH-1 cells?
The culture medium recommended for huH-1 cells is composed of High Glucose DMEM supplemented with appropriate additives to support optimal cell growth and maintenance, add 10% FBS.
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Is virus DNA detected in huH-1 cell line?
Hepatitis B virus (HBV) is detected in the huH-1 cell line with a high transcriptional activity. The huH-1 is one of the cell lines that used extensively to study HBV and carcinogenesis, as HBV integration is a risk factor that has been associated with HBV chronicity and hepatocellular carcinoma
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